A Facile Synthesis of N-alkyl-4'-methyl-1,1'-biphenyl-2-sulfona-mide via Linking DoM React

• 作 者: 章军 周智明 薛为哲 李志怀
• 机 构: Research and Development Center for Pharmaceuticals,School of Chemical Engineering and Environment,B
• 出 处: Journal of Beijing Institute of Technology
• 发表日期: 2009年03期
• 关键词: biphenyl alkyl methyl-1 1 Suzuki readily linking starting amines operate steps

Six N-alkyl-4’-methyl-1,1’-biphenyl-2-sulfonamides were synthesized facilely and efficiently from low cost and readily available benzenesulfonyl chloride and C1-C4 fatty amines via linking DoM reaction with Suzuki reaction.The structures of the new compounds synthesized were confirmed by elemental analysis,IR,1H NMR and MS.This new method makes a feature of low cost and readily available starting material,fewer steps,mild condition,easiness to operate and higher yield.

Six N-alkyl-4’-methyl-1,1’-biphenyl-2-sulfonamides were synthesized facilely and efficiently from low cost and readily available benzenesulfonyl chloride and C1-C4 fatty amines via linking DoM reaction with Suzuki reaction. The structures of the new compound accounting confirmed confirmed by elemental analysis, IR, 1 H NMR and MS. this new method makes a feature of low cost and readily available starting material, fewer steps, mild condition, easiness to operate and higher yield.