论文部分内容阅读
亚甲基双(膦酸二烷基酯)及其衍生物是一类能以通式1表示的化合物,其中1a、1b及1c、1d分别可视为丙二酸酯及乙酰乙酸酯的磷类似物,它们是重要有机合成试剂及金属配位体,但是这类化合物的研究与应用受到其合成方法的限制.本文报道基于甲基膦酸二乙酯(2)碳阴离子的磷(膦)酰化反应合成1的新方法.1的C-烷基化可得预期的3,后者也可由烷基膦酸二乙酯(4)的碳阴离子反应而得,或由二苯基膦酰氯经甲基化及相继的碳阴离子磷酰
Methylenebis (dialkyl phosphonates) and their derivatives are a class of compounds that can be represented by Formula 1, where 1a, 1b, and 1c, 1d, respectively, can be considered as malonate and acetoacetate Phosphorus analogues, which are important organic synthesis reagents and metal ligands, but the research and application of these compounds are limited by their synthesis methods.The paper reports the phosphine (phosphine) based on diethylphosphonic methylphosphonate (2) ) Acylation reaction to synthesize a new method of 1. C-alkylation of 1 gives the expected 3, which can also be obtained by reaction of the carbon anion of alkylphosphonic acid diethyl ester (4) or from diphenylphosphine The acid chloride is methylated and followed by the carbanion phosphoryl