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鼻上颌发育不良的病人有很典型的临床表现,最明显的特征是前鼻嵴缺如,面中份发育不良,包括鼻软组织面中份凹陷,呈“盘状脸”,上唇突,人中宽,鼻小柱短,在鼻和上唇软组织有很深凹陷。另外错(牙合)是常见的,如上切牙拥挤、前倾、切牙反(牙合)、开(牙合)等。1962年 Binder第一次透彻地分析了这种畸形,建议命名为“鼻上颌发育不良”。1976年 Gorlin 决定正式命名为“鼻上颌发育不良”或“Binder's 综合症”。有关“Binder's 综合症”的病因还不清楚。1963年 Hopkin 报道了5例病案,排除了外伤和感染因素是引起前鼻嵴缺如的原因。1976年又有人研究了31例病人,特别注意了患者的鼻呼吸功能是正常的。研究对象:来自瑞典三个地区97名有先天
Nasal maxillary dysplasia patients have a very typical clinical manifestations, the most obvious feature is the absence of the anterior nasal ridge, the surface of the poorly developed, including the surface of the nasal soft tissue surface depression, was “discoid face”, the upper lip suddenly, in the human Wide, short nasal column, deep in the nose and upper lip soft tissue. Another wrong (occlusion) is common, such as crowding incisors, anteversion, incisor (occlusion), open (occlusion) and so on. Binder 1962 for the first time a thorough analysis of this deformity, it is recommended that the name “nasal maxillary dysplasia.” Gorlin decided in 1976 to officially name “Nasal maxillary dysplasia” or “Binder's syndrome.” The cause of “Binder's syndrome” is unclear. Hopkin in 1963 reported five cases, excluding traumatic and infectious factors that cause the absence of the anterior nasal ridge. In 1976, another study of 31 patients, with particular attention to the patient's nasal respiratory function is normal. Research object: 97 from three regions in Sweden are innate