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To evaluate quality of life (QOL) and psychosocial adjustment by standardized tests in well-characterized patients with steroid-sensitive nephrotic syndrome . Forty-five patients were investigated at amedian age of 9.8 years (range, 3 .4 to 19.8) and 5.9 years (range, 0.1 to 16.3) since diagnosis. Child-and parentrated QOL was evaluated by the The Netherlands Organization for Applied Sc ientific Research Academical Medical Center (TNO-AZL) Child Quality of life Que stionnaire. Psychosocial adjustment was assessed by the Child Behavior Checklist and the Teacher Report Form. In patients, only the QOL subscale “social functi oning”was impaired compared with that in control subjects, whereas parents rate d 4 of a total of 7 subscales as abnormal. Psychosocial adjustment was impaired at home and at school. Steroid dependency and cytotoxic treatment had a signific ant negative impact on QOL only, whereas family climate, especially maternal dis tress, negatively affected both QOL and psychosocial adjustment. QOL and psychos ocial adjustment are impaired in steroid-sensitive nephrotic syndrome. Both ill ness-related variables and family climate play an important role.
To evaluate quality of life (QOL) and psychosocial adjustment by standardized tests in well-characterized patients with steroid-sensitive nephrotic syndrome. Forty-five patients were investigated at amedian age of 9.8 years (range, 3.4 to 19.8) and 5.9 years (range, 0.1 to 16.3) since diagnosis. Child-and parentrated QOL was evaluated by the Netherlands Organization for Applied Sc ientific Research Academical Medical Center (TNO-AZL) Child Quality of Life Quetionnaire. Psychosocial adjustment was assessed by Child Behavior In patients, only the QOL subscale “social functi oning” was impaired compared with that in controlling subjects, than parents rate d 4 of a total of 7 subscales as abnormal. Psychosocial adjustment was impaired at home and at Steroid dependency and cytotoxic treatment had a significant ant negative impact on QOL only, while family climate, especially maternal dis tress, negatively affected both QOL and psyc hosocial adjustment. QOL and psychos ocial adjustment are impaired in steroid-sensitive nephrotic syndrome. Both ill ness-related variables and family climate play an important role.