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应用人胸腺素治疗42例病史在1年以上,每月至少复发1次或无间歇且对其它疗法皆无效的轻型口疮及口疮性口炎患者,并于治疗前后分别测定了LTT及ERFT。观察时间由半年至30个月不等。结果为痊愈4例,显效12例,好转21例,无效5例。未发现任何不良反应。免疫学检测结果表明:治疗组口疮患者的LTT及ERFT在治疗前均比对照组低,其差别极显著,但患者在治疗前后对比结果无显著性差异。疗效显著可能与其有增强和调节免疫功能的作用有关。但疗效一般仅维持半年至1年,以后疗效随时间延长而减弱以至消失。
Forty-two patients with mild throat and mouth aphthous stomatitis were treated with human thymosin for at least one year, with at least one recurrence per month or with no intermittent and other treatments. LTT and ERFT were measured before and after treatment. Observation time from six months to 30 months. The results were cured in 4 cases, 12 cases markedly improved in 21 cases, 5 cases ineffective. No adverse reactions were found. The result of immunology showed that the difference of LTT and ERFT before treatment in treatment group was lower than that in control group, but the difference was not significant before and after treatment. Significant effect may be related to its role in enhancing and regulating immune function. However, the general effect is only maintained for six months to 1 year, after the efficacy of the effect weakened or disappeared over time.