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２７例早产儿肺透明膜病（ＨＭＤ）伴呼吸衰竭需要呼吸机治疗者，在２．６９±１．１６天出现动脉导管开放（ＰＤＡ），导管开放时，均有心前区抬举搏动、心音亢强、周围脉搏增强、心脏有杂音、心率增快、脉区差增大，口服消炎痛后，导管关闭。关闭后，心率和脉压差显著下降，ＰａＯ２升高，ＰａＣＯ２下降，与开放时比较均有非常显著差异（Ｐ＜０．００１），提出在ＨＭＤ急性期出现心前区抬举搏动、心音亢强、心率加快、脉压差加大、ＰａＣＯ２升高等，可作为早期诊断动脉导管开放的临床依据。
27 cases of premature neonates with pulmonary hyaline membrane disease (HMD) with respiratory failure required ventilator therapy, with a patent ductus arteriosus (PDA) at 2.69 ± 1.16 days and an anterior precordial pulsatile beating and catheterization Strong, enhanced pulse around, heart murmur, heart rate increased, pulse difference increases, oral indomethacin, the catheter closed. After closure, heart rate and pulse pressure decreased significantly, PaO2 increased, PaCO2 decreased, compared with the open time were very significant differences (P <0.001), proposed in the acute phase of HMD appear precordial beating beating, heart sound hyperthyroidism , Heart rate, pulse pressure increases, PaCO2 increased, can be used as early diagnosis of patent ductus arteriosus clinical basis.