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目前对糖尿病(DM)与脑血管病之间的关系已有较多的论述,而对 DM 与周围神经病变的关系及其治疗尚无系统阐述,现予以初步探讨。DM 周围神经病变的发病机理复杂,可能与下列因素有关:①代谢性和血管性因素。其中 DM 患者葡萄糖转化为山梨醇和果糖升高,使细胞中渗透压升高,Schwann 细胞水肿,引起神经肿胀和脱髓鞘改变,是造成神经损害很重要的原因。②亦有认为本病的发生和神经组织内肌醇减少和 NA+-K+ATP 酶活性降低有关。③高糖状态直接导致神经变性。④DM 时血管闭塞影响
At present, the relationship between diabetes (DM) and cerebrovascular disease has been more discussed, and the relationship between DM and peripheral neuropathy and its treatment is not systematically elaborated, we will be preliminary study. DM peripheral neuropathy complicated pathogenesis, may be related to the following factors: ① metabolic and vascular factors. In DM patients, glucose is converted to sorbitol and fructose increased, the cell osmotic pressure increased Schwann cell edema, causing nerve swelling and demyelination is caused by nerve damage is very important reason. ② There are also that the occurrence of this disease and in the nervous tissue inositol and NA + -K + ATP enzyme activity decreased. ③ high glucose status directly lead to neurodegeneration. ④ DM vascular occlusion