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［目的］研究幽门螺杆菌（Ｈｐ）与胃癌发生之间的关系。［方法］用美蓝染色对７４１例胃炎性病变和１３１例胃癌病人之胃粘膜活检组织的Ｈｐ感染情况进行检测。［结果］胃癌组和慢性萎缩性胃炎组（ＣＡＧ）Ｈｐ检出率分别为６２．５９％和６１．６０％，明显高于慢性浅表性胃炎组（ＣＳＧ）的３８．６１％（Ｐ＜０．０１）；胃癌组中，伴有癌周粘膜肠化生者Ｈｐ检出率明显高于不伴肠化生者（Ｐ＜０．０５）；在活动性ＣＳＧ和ＣＡＧ中，Ｈｐ检出率分别为８９．４１％和９０．５３％，而在非活动性ＣＳＧ和ＣＡＧ中仅分别为１．７１％和１．２３％，两者差异非常显著（Ｐ＜０．０１）。［结论］提示Ｈｐ感染与胃癌的发生有显著的相关性；Ｈｐ有可能通过引发活动性胃炎、腺体萎缩、上皮肠化生等方式参与胃癌的发生。
[Objective] To study the relationship between Helicobacter pylori (Hp) and the occurrence of gastric cancer. [Methods] M.pylori staining was used to detect the Hp infection of gastric mucosal biopsies in 741 cases of gastritis and 131 cases of gastric cancer. [Results] The detection rates of Hp in gastric cancer group and chronic atrophic gastritis group (CAG) were 62.59% and 61.60%, respectively, which was significantly higher than that of chronic superficial gastritis (CSG) group 38.61% (P< In the gastric cancer group, the detection rate of Hp in patients with intestinal metaplasia was significantly higher than those without intestinal metaplasia (P<0.05). In active CSG and CAG, Hp was detected. The rates were 89.41% and 90.53%, respectively, while in inactive CSG and CAG were only 1.71% and 1.23%, respectively. The difference was very significant (P<0.01). [Conclusion] It is suggested that Hp infection has a significant correlation with the occurrence of gastric cancer; Hp may be involved in the occurrence of gastric cancer by triggering active gastritis, gland atrophy, epithelial metaplasia and other forms.