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目的:基于3.0T磁共振磁敏感加权成像(SWI)分析正常新生儿大脑相位位移解剖学规律及其与周龄间相关性,评价SWI在新生儿脑发育评估中的应用价值。方法:根据纳入标准收集80例3.0T MRI脑部SWI扫描正常新生儿,测量双侧深部灰质区、中央皮质区、额叶皮质区及顶叶皮质区相位位移值(PS);计算深部灰质区与大脑皮质区相位位移值平均值的比得到相位位移比率。SPSS 19.0版软件方差分析组间PS值差异;Spearsman相关性分析正常新生儿相位位移比率(PSR)与MRI检查时周龄相关性。结果:1正常新生儿脑深部灰质区PS均值为0.052±0.010;额叶大脑皮质区PS均值为0.059±0.010、中央大脑皮质区PS均值为0.045±0.009、顶叶大脑皮质区PS均值为0.039±0.009;额叶、中央区及顶叶大脑皮质相位位移值均值为0.048±0.009;深部灰质区PS高于大脑皮质平均PS(P<0.01);在大脑皮质中额叶区PS显著高于中央区和枕叶区(P<0.01)。2正常新生儿深部灰质区与大脑皮质区的PSR范围在0.139-2.746。PSR与MRI检查时周龄成负相关(r=-0.35,P=0.04)。结论:正常新生儿大脑PS存在解剖学差异,深部灰质区PS高于皮质区,皮质区PS从高到低为额叶皮质区、中央区和顶叶区;且深部灰质区和大脑皮质区相位位移比率随着妊娠并出生后周龄增长而不同程度降低;SWI的PS测量方法可无创性定量评估新生儿脑发育。
OBJECTIVE: To evaluate the anatomic characteristics of normal newborn brain phase displacement and its relationship with age by 3.0T magnetic resonance susceptibility weighted imaging (SWI), and to evaluate the value of SWI in assessing newborn brain development. Methods: According to the inclusion criteria, 80 cases of 3.0T MRI brain SWI were collected from normal neonates. The phase displacement (PS) of bilateral deep gray matter area, central cortex area, frontal cortex area and parietal cortex area were measured. The ratio of the phase shift to the average value of the phase shift in the cortical area results in a phase shift ratio. SPSS 19.0 software analysis of variance between groups PS value differences; Spearsman correlation analysis of normal newborn phase shift ratio (PSR) and MRI examination week age. The mean PS value of cerebral cortex in frontal cortex was 0.045 ± 0.009, and the mean PS value in parietal cortex was 0.039 ± 0.009, respectively. Mean PSF values in the frontal, central and parietal cortex were 0.048 ± 0.009, PS in the deep gray matter area was higher than that in the cerebral cortex (P <0.01), PS in the frontal cortex in the cerebral cortex was significantly higher than that in the central area And occipital lobe (P <0.01). PSR ranged from 0.139 to 2.766 in normal neonates with deep gray matter and cerebral cortex. There was a negative correlation between PSR and MRI (r = -0.35, P = 0.04). CONCLUSIONS: There is an anatomical difference in the normal neonatal brain PS, PS in the deep gray matter area is higher than that in the cortical area, and PS in the cortical area is from high to low to the frontal cortex, central and parietal areas; and the deep gray matter area and the cerebral cortex area The rate of displacement decreased with the increase of gestational age and the age at birth. The PSI of SWI could evaluate the neonatal brain development noninvasively and quantitatively.