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作者评价Rh(D)阴性健康男性志愿者中一种新的抗-D免疫球蛋白之特性。6位志愿者接受静脉内注射,5位志愿者肌肉注射200μg抗-D,经此处理48小时前注入5mlRh(D)阳性红细胞。静脉注射抗(D)后受者Rh(D)阳性红细胞数立即减少。肌肉注射者的红细胞数下降有6个小时的延迟期,而且去除速率缓慢。注射抗D24小时后,所有志愿者的Rh(D)阳性红细胞均低达可检测的极限水平或不同测得。经静脉内处理者,抗-D血清水平从第2小时的45ng/ml减少至第24小时的29ng/ml,然而肌肉途径者,抗-D于第4小时可测出,并在第24小时升至11ng/ml。在随后的数月中,两组人群中抗-D血清水平下降速
The authors evaluated the properties of a novel anti-D immunoglobulin in Rh (D) negative healthy male volunteers. Six volunteers received an intravenous injection and five volunteers injected intramuscularly 200 μg of anti-D, and 5 ml of Rh (D) positive erythrocytes were injected 48 hours prior to this treatment. The number of Rh (D) -positive erythrocytes in recipients immediately after anti-D (iv) injection decreased immediately. Reduce the number of red blood cells in muscle injectors have a 6-hour delay, and the removal rate is slow. After 24 hours of injection of anti-D, the Rh (D) -positive erythrocytes in all volunteers were as low as the detectable limit level or were measured differently. Anti-D serum levels decreased from 45 ng / ml at 2 hours to 29 ng / ml at 24 hours following intravenous treatment, whereas those of muscle pathways, anti-D, were detectable at 4 hours and at 24 hours Rose to 11ng / ml. In the following months, anti-D serum levels decelerated in both groups