Visualizing the microtubule-associated protein tau in the nucleus

• 作 者: LU Jing LI Ting HE RongQiao BA
• 机 构: ClemJonesCentreforAgeingDementiaResearch,InstituteofBiophysics
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2014年4期
• 关键词: TAU蛋白 微管相关蛋白 细胞核 可视化 转基因小鼠 神经母细胞瘤 亚细胞区室 阿尔茨海默氏病 Alzheimer＇s disease fractionati
• 基金项目: supported by the Estate of Dr.Clem Jones AO and the Aus-tralia-China Joint Laboratory of Neuroscience and Cognition,as well as grants from the Australian Research Council,the National Health and Medic

Although tau is mainly known as an axonal microtubule-associated protein,many studies indicate that it is not restricted to this subcellular compartment.Assessing tau’s subcellular distribution,however,is not trivial as is evident from transgenic mouse st