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目的:寻找一种助溶剂,克服呋喃西林在较低温度下易从溶液中析出的问题,并初步预测制剂的稳定性。方法:配制各种复方溶液.于低温保存,筛选出最佳助溶剂及其使用浓度,然后采用初均速法预测溶液的稳定性。结果:硼酸对呋喃西林有助溶作用,有效浓度为1.2%~2.0%,20℃以下环境保存,有效期可达3年。结论:与苯甲酸钠等物质比,硼酸的助溶效果好,尤其适宜于低温环境,所配制剂稳定。
OBJECTIVE: To find a cosolvent to overcome the problem that nitrofurazone is easily precipitated from solution at lower temperature, and to predict the stability of the preparation initially. Methods: Prepare all kinds of compound solution, store at low temperature, filter out the optimal concentration of cosolvent, and then use the average initial velocity method to predict the stability of the solution. Results: Boric acid has a solubilizing effect on nitrofurazone with an effective concentration of 1.2% -2.0%. It can be stored in the environment below 20 ℃ for up to 3 years. Conclusion: Compared with sodium benzoate and other substances, boric acid has a good effect of solubilizing, especially suitable for low temperature environment, and the formulation is stable.