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为提高土霉素的稳定性,延长其作用时间,提高药物疗效,以单硬脂酸甘油酯为载体材料,采用乳化蒸发-低温固化法制备土霉素固体脂质纳米粒并对其形态、粒径、Zeta电位、包封率、稳定性和体外释药特性等进行研究。结果显示,所制备的土霉素固体脂质纳米粒外观形态圆整,分散指数为0.512,平均粒径为345.8nm,Zeta电位为-34.7mV,平均包封率为51.25%,载药量为102.5mg/g,4℃放置1个月,包封率、载药量无显著变化。药物的体外释药试验表明制备的纳米粒具有显著缓释作用。结果表明,制备的土霉素固体脂质纳米粒粒径分布范围窄,稳定性较好,对土霉素的释放具有明显的缓释效应。
In order to improve the stability of oxytetracycline, prolong its action time and improve the curative effect of drug, glyceryl monostearate was used as carrier material to prepare oxytetracycline solid lipid nanoparticles by emulsion evaporation-low temperature solidification method and its morphology, Particle size, Zeta potential, entrapment efficiency, stability and in vitro release characteristics were studied. The results showed that the prepared oxytetracycline solid lipid nanoparticles had a round appearance shape, a dispersion index of 0.512, an average particle diameter of 345.8 nm, a Zeta potential of -34.7 mV and an average entrapment efficiency of 51.25% 102.5mg / g, 4 ℃ for 1 month, encapsulation efficiency, drug loading no significant change. In vitro drug release test showed that the prepared nanoparticles have a significant sustained release effect. The results showed that the prepared oxytetracycline solid lipid nanoparticles have a narrow range of particle size distribution and good stability, and have obvious sustained release effects on the release of oxytetracycline.