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白血病细胞的多药耐药(MDR)的产生是导致化疗失败的主要原因。目前发现 MDR 的产生机制是多因素的,且有不同的耐药表型。核转录因子 Kappa B(NF-KB)在细胞增殖和凋亡中起关键调控作用。为明确 NF-KB 是否与细胞 MDR产生有关及葛根素是否通过抑制 NF-KB 活性而逆转耐药,我们观察了慢性粒细胞白血病急变细胞株 K562及其耐药细胞
Leukemia cell multidrug resistance (MDR) is the leading cause of chemotherapy failure. It is now found that the mechanism of MDR is multifactorial and has different resistance phenotypes. The nuclear transcription factor Kappa B (NF-KB) plays a key regulatory role in cell proliferation and apoptosis. To determine whether NF-κB is involved in cell MDR production and whether puerarin reverses drug resistance by inhibiting NF-κB activity, we investigated the effects of K562 and its drug-resistant cells on chronic myeloid leukemia