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为研究中药复方 962胶囊对老龄大鼠皮质胆碱乙酰转移酶 (ChAT)和乙酰胆碱酯酶 (AchE)活性的影响 ,将2 2月龄和 2 4月龄Wistar大鼠分为青年对照组、老年模型组、阳性对照脑复康组 ( 0 .56g/kg)、962中剂量组 ( 0 .9g/kg)和 962大剂量组 ( 1 .8g/kg) 5组 ,分别灌胃给药 1～ 2个月后处死大鼠。用Fonnun法和羟胺比色法分别测定 5组大鼠皮质的ChAT和AchE的活性。结果 :中药复方 962大剂量 ( 1 .8g/kg)对老龄大鼠皮质ChAT活性有提高作用 (P <0 .0 5) ,但对AchE无显著影响。提示 :中药复方 962可能通过影响老龄大鼠中枢胆碱能神经系统而改善其衰老的变化
In order to study the effect of 962 capsules on the activity of choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) in cortex of aged rats, 22-month-old and 24-month-old Wistar rats were divided into young control group and old people. In the model group, the positive control Naofukang group (0.56g/kg), the 962 medium dose group (0.9g/kg), and the 962 large dose group (1.8g/kg) 5 groups, respectively Rats were sacrificed 2 months later. The activity of ChAT and AchE in the cortex of 5 groups of rats was determined by the Fonnun method and hydroxylamine colorimetry respectively. RESULTS: The 962 large dose (1.8 g/kg) of traditional Chinese medicine compound had an effect on the increase of ChAT activity in aged rats (P < 0.05), but it had no significant effect on AchE. Tip : Chinese Herbal Compound 962 may improve aging by altering the central cholinergic nervous system in aged rats