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目的:观察电刺激小脑顶核(fastigialnucleus,FN)结合康复训练治疗急性脑梗死的疗效。方法:入选急性期颈内动脉系统脑梗死患者139例,随机分为3组,治疗组49例,接受FN电刺激结合康复治疗;康复组46例,单纯康复治疗;对照组44例,单纯药物治疗,所有患者其他治疗按神经内科常规。在治疗前和治疗后8周分别进行美国国立卫生研究院卒中量表(NIHSS)、简式Fugl-Meyer评分(FMA)、Barthel指数(MBI)评定以观察疗效。结果:治疗前3组患者各项功能评分之间差异无显著性意义(P>0.05),治疗后:NIHSS,治疗组为3.53±3.28,康复组为4.67±4.14,对照组为5.73±4.54,组间比较差异有显著性意义(F=4.323,P=0.016);FMA和MBI评分治疗后治疗组和康复组均优对照组,而且治疗组优于康复组(P<0.05)。结论:电刺激小脑顶核结合康复训练能够有效改善急性脑卒中患者的功能预后。
Objective: To observe the effect of electrical stimulation of fastigial nucleus (FN) and rehabilitation training on acute cerebral infarction. Methods: One hundred and ninety-three patients with acute cerebral infarction of internal carotid artery were enrolled and randomly divided into three groups. The treatment group received 49 cases of FN electrical stimulation combined with rehabilitation. The rehabilitation group received 46 cases of simple rehabilitation, while the control group of 44 cases received simple drug Treatment, all other patients treated by neurology routine. NIHSS, Fugl-Meyer score (FMA) and Barthel index (MBI) were assessed before and 8 weeks after treatment to observe the effect. Results: There was no significant difference in functional scores between the three groups before treatment (P> 0.05). After the treatment, NIHSS was 3.53 ± 3.28 in the treatment group, 4.67 ± 4.14 in the rehabilitation group and 5.73 ± 4.54 in the control group, The differences between the two groups were significant (F = 4.323, P = 0.016). The scores of FMA and MBI in both treatment group and rehabilitation group were better than those in rehabilitation group (P <0.05). Conclusion: Electrical stimulation of cerebellar fastigial nucleus combined with rehabilitation training can effectively improve the prognosis of patients with acute stroke.