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目的探讨乌司他丁对慢性阻塞性肺疾病(COPD)患者的疗效及对肺功能的影响。方法 60例COPD患者,按照数字随机法分为对照组和观察组,每组30例。对照组给予常规对症治疗,观察组在对照组基础上给予乌司他丁治疗,比较两组患者疗效以及肺功能变化,机械通气时间及住院时间。结果观察组总有效率为83.3%,高于对照组的53.3%(P<0.05)。治疗后,观察组氧合指数(PaO_2/FiO_2)为(358.3±26.5)mm Hg(1 mm Hg=0.133 kPa),优于对照组的(289.6±22.7)mm Hg;观察组第一秒用力呼气容积/用力肺活量(FEV1/FVC)为(78.3±6.5)%,优于对照组的(64.6±6.7)%;观察组机械通气时间、住院时间均短于对照组(P<0.05)。结论乌司他丁对COPD患者疗效较佳,可有效改善肺功能,具有良好应用前景。
Objective To investigate the effect of ulinastatin on lung function in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty COPD patients were divided into control group and observation group according to the digital random method, with 30 cases in each group. The control group was given conventional symptomatic treatment. The observation group was treated with ulinastatin on the basis of the control group. The curative effect, lung function, mechanical ventilation time and hospital stay of the two groups were compared. Results The total effective rate in the observation group was 83.3%, which was higher than that in the control group (53.3%, P <0.05). After treatment, the oxygenation index (PaO_2 / FiO_2) in the observation group was (358.3 ± 26.5) mm Hg (1 mm Hg = 0.133 kPa), which was superior to that of the control group (289.6 ± 22.7 mm Hg) The volume of air / forced vital capacity (FEV1 / FVC) was (78.3 ± 6.5)% better than that of the control group (64.6 ± 6.7)%. The duration of mechanical ventilation and hospital stay in the observation group were shorter than those in the control group (P <0.05). Conclusion Ulinastatin has better curative effect on patients with COPD, which can effectively improve pulmonary function and has good application prospect.