论文部分内容阅读
本实验表明感染曼氏血吸虫大鼠的血小板在体液因子IgE的参与下具有杀童虫作用。血小板仅占人体血液总细胞容量的约5%,白细胞容量的34%。它除了可溶解抗体一包涂的红细胞外,并未见有其对病原体的细胞毒作用的报导。在Fisher大鼠感染曼氏血吸虫期间,当对再感染免疫力达高水平的第54天,血小板杀虫性质高达98%,而同样在大鼠感染后第45天血流内血小板数量亦增加至正常水平的3倍。此后,两种参数均迅速下降。从感染动物分离的血小板细胞毒性在小牛血清中比在自身血清中下降5～10%。因此疑及感染血清中存在某种能诱导血小板活性的因子,而它也可以激活正常动物的血小板,其最高值为在感染后42天的血清。此种
This experiment shows that the platelets infected with Schistosoma mansoni have the role of killing the worms with the involvement of humoral factor IgE. Platelets account for only about 5% of the total human blood cell volume and 34% of the white blood cell volume. In addition to its ability to dissolve antibody-coated red blood cells, no cytotoxic effects on pathogens have been reported. During Fisher’s infection with Schistosoma mansoni, platelet insecticidal properties were as high as 98% on day 54 of high re-infectivity immunity and also increased to within 45 days of infection 3 times the normal level. Since then, both parameters have dropped rapidly. Platelet cytotoxicity isolated from infected animals decreases 5 to 10% in calf serum compared to autologous serum. Therefore, it is suspected that there is some factor that induces platelet activity in infected sera, and it also activates platelets in normal animals with a maximum of 42 days after infection. This kind