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雄性ＳＤ大鼠饮用含苯巴比妥钠（１ｍｇ／ｍｌ）的饮水１周后，随机分为四组，每组８例，分别吸入：Ｃ，１４％Ｏ＿２／８６％Ｎ＿２；Ｅ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ安氟醚；Ｓ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ七氟醚；Ｈ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ氟烷１ｈ。２４ｈ后发现Ｈ组血浆ＡＬＴ活性显著高于其它各组，并有明显的小叶中心性肝细胞坏死及汇管区炎细胞浸润，血窦重度充血。Ｅ组可见部分肝小叶内有小叶中心性坏死及空泡变性。Ｈ组肝匀浆及血浆中ＴＸＢ＿２含量显著高于其它各组。６－ｋｅｔｏ－ＰＧＦ１ａ各组间均无显著差异。提示氟烷性肝炎与ＴＸＡ＿２／ＰＧＩ＿２平衡失调有一定的关系。
One week after drinking water containing phenobarbital (1mg / ml), male SD rats were randomly divided into four groups with 8 cases in each group: C, 14% O 2/86% N 2; E, 14% O 2/86% N 2 / 1.2MAC enflurane; S, 14% O 2/86% N 2 / 1.2MAC sevoflurane; H, 14% O 2/86% N 2 / 1.2MAC halothane 1h. After 24 h, the plasma ALT activity in group H was significantly higher than that in other groups, with obvious necrosis of centrilobular hepatocytes and inflammatory cell infiltration in portal area and severe congestion of sinusoids. E group of visible part of the hepatic lobule lobular central necrosis and vacuolar degeneration. H group liver homogenate and plasma TXB_2 content was significantly higher than the other groups. There was no significant difference between 6-keto-PGF1a groups. Hint Fluoride hepatitis and TXA 2 / PGI 2 balance disorders have a certain relationship.