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自从了解到亚硝胺化合物的工业危害以后,它们的毒理学就引起了很大的注意。特别是:甲基亚硝胺,在美国一汽车厂中曾用作为溶剂,两名工人因事故而中毒,一人从肝损伤疾病中恢复了;另一人死亡,从病理解剖中发现肝硬化并伴有结节性再生。在英国工业研究实验室中,有三人中毒,二人接触10个多月,有肝损伤症状,另一人死于支气管肺炎,病理解剖发现有肝硬化。在其他的技术员中发现肝质地变硬而且表面不规则,但是在终止接触后得到了恢复。1956年Magee和Barnes在鉴
Their toxicology has attracted a great deal of attention since they learned about the industrial hazards of nitrosamines. In particular: Methylnitrosamine, used as a solvent in a U.S. auto plant, two workers were poisoned due to an accident and one recovered from a liver injury; one died, and cirrhosis was found from the pathological anatomy There are nodular regeneration. In the British Industrial Research Laboratory, three people were poisoned. Two people contacted for more than 10 months and had symptoms of liver injury. The other died of bronchopneumonia and pathological findings showed cirrhosis. It was found by other technicians that the liver hardens and the surface is irregular, but recovered after termination of the contact. 1956 Magee and Barnes in the Kam