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目的观察逐瘀通脉胶囊对脑梗死氧化因子MDA、8-OHdG的影响。方法将缺血性脑中风患者120例,按随机数字表法随机分为对照组与观察组,各60例。对照组在控制血压、血糖、血脂的基础上,给予常规扩血管类药物和神经营养药物治疗,阿司匹林片0.25mg,3次/d,口服。连续治疗1个月。观察组在对照组治疗的基础上,口服逐瘀通脉0.4g,3次/d。连续治疗1个月。观察血清氧化应激相关因子MPO水平变化。结果在血清SOD、T-AOC、MDA、8-OHdG、GSH-Px水平比较中,二组间治疗前比较,均差异无统计学意义(P>0.05);二组组内比较和二组间治疗后比较,均差异有统计学意义(P<0.05),观察组治疗后血清MDA、8-OHdG低于治疗前和对照组治疗后,而观察组治疗后血清SOD、TAOC、GSH-Px高于治疗前和对照组治疗后。各组患者治疗后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、血液流变学指标及高敏C反应蛋白均较治疗前显著好转,且观察组优于对照组。结论逐瘀通脉胶囊可有效的降低MDA、8-OHdG水平,提高SOD、T-AOC、GSH-Px水平,改善调节血脂、高敏C反应蛋白。
Objective To observe the effect of Zhuyu Tongmai capsule on the oxidative factors MDA and 8-OHdG in cerebral infarction. Methods 120 cases of ischemic stroke patients were randomly divided into control group and observation group according to the random number table method, 60 cases each. Control group in the control of blood pressure, blood glucose, blood lipids based on the conventional vasodilators and neurotrophic drugs given, aspirin tablets 0.25mg, 3 times / d, orally. Continuous treatment for 1 month. Observation group in the control group based on the treatment, oral Zhuyu Tongmai 0.4g, 3 times / d. Continuous treatment for 1 month. The changes of serum oxidative stress related factor MPO level were observed. Results There was no significant difference in serum SOD, T-AOC, MDA, 8-OHdG and GSH-Px between the two groups before treatment (P> 0.05) After treatment, the difference was statistically significant (P <0.05). After treatment, serum MDA and 8-OHdG in the observation group were lower than those before treatment and in the control group, while the levels of SOD, TAOC and GSH-Px in the observation group were significantly higher Before treatment and control group after treatment. After treatment, the levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), hemorheology indexes and high-sensitivity C-reactive protein Both were significantly better than before treatment, and the observation group was better than the control group. Conclusion Zhuyu Tongmai Capsule can effectively reduce the levels of MDA and 8-OHdG, increase the levels of SOD, T-AOC and GSH-Px, and improve the regulation of blood lipids and high-sensitivity C-reactive protein.