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[目的]探讨接受血透治疗的终末期肾病(ESRD)病人血浆网膜素水平变化及其与体重指数(BMI)、血清肌酐(Scr)、血糖、血脂、胰岛素抵抗指数的关系。[方法]收集62例ESRD病人(男32人,女30人)资料,同时选取年龄匹配的肾功能正常的健康成人80例做为正常对照组。采用酶联免疫法测定空腹血浆网膜素水平,采用稳态模型评估法(Homa-IR)计算胰岛素抵抗指数,并分析血浆网膜素与BMI、血脂、血糖及Homa-IR等的关系。[结果]ESRD病人血清网膜素水平明显高于正常人(P<0.01),ESRD组伴有糖尿病者网膜素水平又明显低于无糖尿病的病人(P<0.01)。血浆网膜素水平与BMI、Homa-IR呈负相关,与高密度脂蛋白胆固醇、Scr水平呈明显正相关(r=0.424,P<0.01)。[结论]ESRD病人血浆网膜素水平较健康者升高,ESRD病人合并糖尿病者血浆网膜素水平较未合并糖尿病病人低。
[Objective] To investigate the changes of plasma retinin in end-stage renal disease (ESRD) patients undergoing hemodialysis and its relationship with body mass index (BMI), serum creatinine (Scr), blood glucose, blood lipid and insulin resistance index. [Methods] The data of 62 ESRD patients (32 males and 30 females) were collected. Meanwhile, 80 matched age-matched normal healthy adults were selected as the normal control group. Fasting plasma retinin levels were determined by enzyme-linked immunosorbent assay. Insulin resistance index was calculated by Homa-IR. The relationship between plasma retinin and BMI, serum lipids, blood glucose and Homa-IR were analyzed. [Results] Serum omentin levels in patients with ESRD were significantly higher than those in normal controls (P <0.01). The levels of emodin in ESRD patients with diabetes were significantly lower than those without diabetes (P <0.01). Plasma retinulin levels were negatively correlated with BMI and Homa-IR, and positively correlated with high-density lipoprotein cholesterol and Scr (r = 0.424, P <0.01). [Conclusion] The level of plasma retinin in patients with ESRD is higher than that in healthy people, and the level of plasma retinin in ESRD patients with diabetes is lower than that in non-diabetic patients.