论文部分内容阅读
五、奥洛他定与其他药物的比较研究奥洛他定与其他药物相比在疗效和舒适性方面均具有显著优势。一项研究评价了奥洛他定和0.5%酮洛酸(非甾体类抗炎滴眼液)用于缓解季节性过敏性结膜炎的眼痒、充血和舒适性,这是一项随机双盲、对侧眼安慰剂对照、交叉的CAC研究(n=36)。在致敏前27分钟用药,致敏后3、10和20分钟后评价眼痒和充血,用标准化不舒适量表评价舒适性。在所有3个时点,在统计学和临床上奥洛他定均比安慰剂能显著减少眼痒和充血;与安慰剂相比,酮洛酸减轻眼痒不显著,相反由于药物刺激它能增加充血(10分钟后评价,P<0.05)。在舒适性方面,奥洛他定显著优于酮洛酸。
Fifth, olopatadine compared with other drugs olopatadine compared with other drugs in the efficacy and comfort have a significant advantage. One study evaluated the effects of olopatadine and 0.5% ketorolac (non-steroidal anti-inflammatory eye drops) on the itch, congestion and comfort of seasonal allergic conjunctivitis, a randomized double Blind, contralateral placebo-controlled, crossover CAC study (n = 36). 27 minutes before sensitization, 3, 10 and 20 minutes after sensitization, itching and congestion were evaluated, and comfort was evaluated using a standardized discomfort scale. Oraltitan, both statistically and clinically, significantly reduced itching and congestion at both 3 statistic times and placebo, compared with placebo; ketorolac had no significant effect on itching compared with placebo, but on the contrary, Increased congestion (evaluated after 10 minutes, P <0.05). Olopatadine is significantly better than ketorolac in terms of comfort.