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选择昆明种小白鼠48只,分为6组,每组8只,雌雄各半。采用骨髓微核试验法研究80g/kg 和40g/kg·体重二种剂量的黄芪有无致突变性及其对环磷酰胺致突变作用的影响。发现二种剂量的黄芪对环磷酰胺的致突变作用育明显的抑制作用,与阳性对照组比较有显著差异,P<0.05。黄芪本身没有致突变性,与空白对照组比较P>0.05。
Select Kunming mice 48, divided into 6 groups, each group of 8, male and female. The bone marrow micronucleus test was used to investigate the mutagenicity of Astragalus membranaceus at doses of 80g / kg and 40g / kg · body weight and its effect on the mutagenicity of cyclophosphamide. It was found that the two doses of Astragalus had a significant inhibitory effect on the mutagenicity of cyclophosphamide, which was significantly different from the positive control group (P <0.05). Astragalus itself mutagenicity, compared with the blank control group P> 0.05.