Polymorphism of the 86th amino acid in CX26 protein and hereditary deafness

• 作 者: Xi Shi Shiwei Qiu Fendong Yan
• 机 构: InstituteofAudiologyandBalanceScience,DepartmentofOtolaryngologydHead&,NeckSurgery,ClinicalHearin
• 出 处: 中华耳科学杂志：英文版
• 发表日期: 2016年2期
• 关键词: HEREDITY DEAFNESS CX26 SGN Heredity deafness CX26 SGN
• 基金项目: supported by grants from the National Basic Research Program of China (973 Program) (#2012CB967900),National Natural Science Foundation of China (31300624, 81470684),Postdoctoral Science Foundation of

Objective: To investigate the membrane localization function of the CX26 protein when its 86 th amino acid is Thr, Ser or Arg, and its relations to deafness.Methods: CX26-GFP protein with either Thr, Ser or Arg as the 86 th amino acid was expressed in mou