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Ten aromatic derivatives of β-aminopropionic acid and γ-aminobutyric acid were prepared.Their compositions and structures were identified by elemental analysis,IR,and 1H NMR.They have been examined for their antibacterial action against Staphylococcua aurens and Escherichia coli.These compounds showed higher activity than the aromatic derivatives of ct-amino acid which were reported previously.The general conclusion to be drawn is that the distance between amino and carboxylic group in these molecules could affect their antibacterial activity.Furthermore,those compounds with p-methyl substituent in phenyl ring exhibit higher activity than the others,and all the compounds exhibit higher activity against Escherichia coli and against Staphylococcua aureus.
Ten aromatic derivatives of β-aminopropionic acid and γ-aminobutyric acid were prepared. These compositions and structures were identified by elemental analysis, IR, and 1H NMR. They have been examined for their antibacterial action against Staphylococcus aurens and Escherichia coli. These compounds showed higher activity than the aromatic derivatives of ct-amino acid which were reported previously. the general conclusion to be drawn is that the distance between amino and carboxylic group in these molecules could affect their antibacterial activity. Future, those compounds with p-methyl substituent in phenyl ring exhibit higher activity than the others, and all the compounds exhibit higher activity against Escherichia coli and against Staphylococcus aureus.