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目的对164例身材矮小儿童进行病因及其相关分析。方法对164例矮小儿童进行全面的病史采集和体格检查及相关实验室检查,另选20名健康儿童为对照组。结果164例中,特发性矮小(ISS)86例(占52.4%),其中包括体质性青春发育延迟(CDGP)及家族性矮小(FSS);生长激素缺乏症(GHD)57例(占34.8%),其IGF-1及IGFBP-3水平较正常对照显著降低,差异有统计学意义(P<0.01);宫内发育迟缓者(IUGR)15例(占9.1%);Turner综合征6例(占3.7%)。结论就诊的矮小儿童中以特发性矮小最为多见,其次为生长激素缺乏症;测定IGF-1及IGFBP-3水平可作为筛查和诊断GHD有价值的指标。对矮小患儿应明确病因,给予对因治疗。
Objective To analyze the etiology and its correlation of 164 cases of short stature children. Methods A total of 164 cases of short children were collected for medical history and physical examination and related laboratory tests. Twenty healthy children were selected as the control group. Results A total of 164 patients (52.4%) had idiopathic short stature (ISS), including constitutional puberty retardation (CDGP) and familial short stature (FSS); 57 cases of growth hormone deficiency (GHD) (P <0.01); intrauterine growth retardation (IUGR) in 15 cases (9.1%); Turner syndrome in 6 cases (3.7%). Conclusions Idiopathic short stature is the most common symptom in short stature children, followed by growth hormone deficiency. The determination of IGF-1 and IGFBP-3 levels may be valuable as a valuable indicator for screening and diagnosis of GHD. Shortage of children should be a clear cause, given due to treatment.