优降糖与美吡达在细胞水平上降血糖作用机理的探讨

• 作 者: 黄丹珊 施曼珠 贾培红 王淑凤
• 机 构: 北京医科大学第一医院内分泌科
• 出 处: 中国糖尿病杂志
• 发表日期: 1996年01期
• 关键词: 美吡达 优降糖 胰岛素分泌 β细胞 磺脲类降糖药 降血糖作用 葡萄糖浓度 葡萄糖代谢 单层培养细胞 纤维母细胞

应用新生大鼠胰腺单层培养β细胞灌流系统研究优降糖与美吡达对胰岛素刺激的效果。含有１６．７ｍｍｏｌ／Ｌ葡萄糖的培养基中维持培养的β细胞，分别在优降糖与美吡达刺激下，０天与７天全程培养期中均引起胰岛素分泌。结果：１６．７ｍｍｏｌ／Ｌ葡萄糖浓度时优降糖刺激效果更为显著，而美吡达刺激效果相对减弱且胰岛素高峰出现迟于优降糖。从而得知：尽管优降糖与美吡达同是磺脲类降糖药，但就其细胞水平上两者的作用机理可能有差异，从其总的刺激效果来看美吡达弱于优降糖。

Study on Effects of Glibenclamide and Glipizide on Insulin Stimulation in Rat Pancreatic Monolayer Cultured β Cell Perfusion System. Cultured β-cells were maintained in media containing 16.7 mmol / L glucose, which all induced insulin secretion throughout the 0 and 7 days of stimulation with glyburide and meperidine. Results: The effect of hypoglycemic stimulation was more obvious when the concentration of glucose was 16.7mmol / L, while the stimulation effect of pyridosterazine was relatively weaker and the peak of insulin was later than that of hypoglycemic. It is learned that: although glyburide glyburide and the United States with sulfonylurea hypoglycemic agents, but its cellular level on the mechanism of action may be different from the total stimulus effect of the United States than weaker than excellent Hypoglycemic