【摘 要】
：
目的 探讨去整合素-金属蛋白酶12(ADAM12)与多种血清肿瘤标志物联合检测在乳腺癌中的临床诊断价值.方法 选择40例乳腺癌患者纳入乳腺癌组,50例乳腺良性疾病患者纳入乳腺良性疾病组,40例体检健康者纳入健康对照组.采用酶联免疫吸附试验检测血清中ADAM12水平,采用电化学发光免疫分析法检测癌胚抗原(CEA)、糖类抗原(CA)125、CA15-3、甲胎蛋白(AFP)和CA19-9水平.比较3组间ADAM12及5项血清肿瘤标志物水平和阳性率.结果 乳腺癌组ADAM12、CEA、CA125、CA15-3、A
【机 构】
：
暨南大学第二临床医学院/深圳市人民医院检验科,广东深圳 518020
论文部分内容阅读
目的 探讨去整合素-金属蛋白酶12(ADAM12)与多种血清肿瘤标志物联合检测在乳腺癌中的临床诊断价值.方法 选择40例乳腺癌患者纳入乳腺癌组,50例乳腺良性疾病患者纳入乳腺良性疾病组,40例体检健康者纳入健康对照组.采用酶联免疫吸附试验检测血清中ADAM12水平,采用电化学发光免疫分析法检测癌胚抗原(CEA)、糖类抗原(CA)125、CA15-3、甲胎蛋白(AFP)和CA19-9水平.比较3组间ADAM12及5项血清肿瘤标志物水平和阳性率.结果 乳腺癌组ADAM12、CEA、CA125、CA15-3、AFP、CA19-9的水平明显高于乳腺良性疾病组、健康对照组,乳腺良性疾病组ADAM12和CA125水平明显高于健康对照组,差异均有统计学意义(P<0.05).乳腺癌组、乳腺良性疾病组和健康对照组ADAM12的阳性率分别为87.50％、30.00％和17.50％;ADAM12联合5项血清肿瘤标志物检测在乳腺癌组、乳腺良性疾病组和健康对照组中的阳性率分别为95.00％、32.00％和20.00％,差异有统计学意义(P<0.05).结论 ADAM12联合CEA、CA125、CA15-3、AFP、CA19-9检测可有效提高乳腺癌筛查的阳性率,具有作为乳腺癌诊断标志物的潜能.
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