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目的分析自然流产夫妇的异常核型发生率,探讨自然流产与染色体核型异常之间的关系。方法对182例反复流产夫妇行外周血染色体分析。结果检出异常染色体核型21例,占受检夫妇的11.5%。异常核型中,大Y染色体、平衡易位者例数相等,占异常核型的47.6%,平衡易位者中相互易位8例,罗伯逊易位1例,染色体多态性2例。结论对于不明原因的自然流产夫妇,染色体分析应作为常规的检测方法。
Objective To analyze the incidence of abnormal karyotype in spontaneous abortion couples and to explore the relationship between spontaneous abortion and chromosomal abnormalities. Methods 182 cases of recurrent miscarriage couples line of peripheral blood chromosome analysis. Results 21 cases of abnormal chromosome karyotype detected, accounting for 11.5% of the couple examined. Abnormal karyotype, the large Y chromosome, balanced translocation of the same number of cases, accounting for 47.6% of abnormal karyotype, translocation in the balance of translocations in 8 cases, Robertson translocation in 1 case, 2 cases of chromosomal polymorphisms. Conclusion For unexplained spontaneous abortion couples, chromosome analysis should be used as a routine test.