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目的:探讨原发性结直肠非霍奇金淋巴瘤(NHL)临床病理因素与预后的关系。方法:回顾1978年5月至2003年3月收治的54例原发性结直肠非霍奇金淋巴瘤资料,采用单因素和多因素方法分析临床、病理、治疗方式与预后的关系。结果:5年总生存率为58.5%,10年总生存率为55.7%。单因素分析显示有无B症状、血清乳酸脱清酶(LDH)水平、病理免疫表型(T/B)、是否行根治性手术切除和临床分期与结直肠非霍奇金淋巴瘤的预后相关,多因素分析显示病理免疫表型(T/B)、临床分期与预后相关。结论:病理免疫表型(T/B)和临床分期是原发性结直肠非霍奇金淋巴瘤独立的不良预后因素。T细胞性淋巴瘤预后较差,临床分期越晚预后越差。
Objective: To investigate the relationship between the clinicopathologic factors and prognosis of primary colorectal non-Hodgkin’s lymphoma (NHL). Methods: The data of 54 patients with primary colorectal non-Hodgkin’s lymphoma from May 1978 to March 2003 were retrospectively analyzed. The relationship between clinical, pathological, treatment and prognosis was analyzed by univariate and multivariate analysis. Results: The overall 5-year survival rate was 58.5% and the 10-year overall survival rate was 55.7%. Univariate analysis showed the presence or absence of B symptoms, serum LDH level, pathological immunophenotype (T / B), radical surgery and clinical stage were associated with the prognosis of colorectal non-Hodgkin’s lymphoma , Multivariate analysis showed that the pathological immunophenotype (T / B), clinical stage and prognosis. Conclusion: The pathological immunophenotype (T / B) and clinical stage are independent prognostic factors of primary colorectal non-Hodgkin’s lymphoma. T-cell lymphoma prognosis is poor, the later the clinical stage the worse the prognosis.