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构建逆转录病毒载体（LNHcTL），将单纯疱疹1型病毒胸苷激酶（HSV1-TK）基因导人人肝癌SMMC7721细胞，用其建立无环鸟苷（ACV）诱导的裸鼠皮下人肝癌移植性肿瘤治疗模型，并将产生复制缺陷型逆gli录病毒的小鼠包装细胞（PA317／LNHcTL）注入肝癌患者的瘤块内，静脉注射ACV。结
Construction of retroviral vector (LNHcTL) and introduction of herpes simplex virus type 1 thymidine kinase (HSV1-TK) gene into human hepatocellular carcinoma SMMC7721 cells to establish acyclovir-induced nude mice subcutaneous human liver cancer transplantation In the tumor treatment model, mouse packaging cells (PA317/LNHcTL) producing replication-defective retro gligeviruses were injected into the tumor mass of liver cancer patients and intravenously injected with ACV. Knot