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本研究的目的是阐明载脂蛋白(apo)E等位基因多态性和日本心肌缺血病人(IHD)之间的关系。另外检查apoE等位基因和IHD病人高脂蛋白血症(HLP)之间的相互关系。结果发现,apoE2组(apoE 3/2,E2/2,E 4/2)的频率IHD病人组与对照组相比(14。7%:7.1%)是有意义地升高,apoE 4组(apo4/3,E4,/4E4/2)频率病人组与对照组比(32。1%:21.7%)也是有意义地升高,而apoE 3/3表型频率IHD病人与对照组相比(54.1%:71.9%)是有意义降低。多数IHD病人为某一型HLP,在IHO病人中apoE2和E4携带者的HLP频率比IHD病人E3/3携带者较高,分别为87.8%,88.6%比78.0%。但这些差异在统计学上
The purpose of this study was to elucidate the relationship between the polymorphism of the apolipoprotein (apo) E allele and Japanese patients with myocardial ischemia (IHD). In addition, the correlation between apoE alleles and hyperlipoproteinemia (HLP) in IHD patients was examined. The results showed that the frequency of apoE2 (apoE 3/2, E2 / 2, E 4/2) patients with IHD was significantly increased compared with the control group (14.7% vs 7.1% (32.1% vs. 21.7%) in patients with apoE 3/3, E4, and / or 4E4 / 2 frequency was also significantly higher than those in controls 54.1%: 71.9%) is a meaningful decrease. The majority of IHD patients have one type of HLP, and the HLP frequency of apoE2 and E4 carriers is higher in IHO patients than in IHD patients E3 / 3 carriers, with 87.8% and 88.6% versus 78.0%, respectively. But these differences are statistically significant