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糖尿病患者大血管病变的风险明显高于普通人群,即使严格控制血糖仍很难显著降低缺血性心血管事件的发生。大量的临床及实验室研究结果表明,糖尿病患者大血管病变危险性增高的主要原因与胰岛素抵抗(IR)以及高血糖所导致的血管内皮细胞(EC)功能受损有关。血管内皮是具有旁分泌、自分泌及内分泌功能的重要器官,EC所释放的多种作用迥异的血管活性因子如一氧化氮(NO)、内皮素-1、前列环素、血管紧张素原等,通过旁分泌及自分泌的
Diabetic patients with macrovascular disease risk was significantly higher than the general population, even if the strict control of blood glucose is still very difficult to significantly reduce the occurrence of ischemic cardiovascular events. A large number of clinical and laboratory studies have shown that the major causes of the increased risk of macrovascular disease in patients with diabetes are related to insulin resistance (IR) and impaired vascular endothelial cell (EC) function induced by hyperglycemia. Endothelium is an important organ with paracrine, autocrine and endocrine functions. A variety of different vasoactive factors released by EC, such as nitric oxide (NO), endothelin-1, prostacyclin and angiotensinogen, By paracrine and autocrine