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目的分析高分级脑胶质瘤术后三维适行放疗及三维适行放疗加化疗的疗效。方法对57例高分级脑胶质瘤进行临床观察,单纯放射治疗(单放)组29例,放射治疗加化疗(综合)组28例。两组患者均在术后2~4周开始常规三维适行放射治疗,综合组第1天加用化疗,方案为替尼泊甙100 mg,氟尿嘧啶750 mg第1~5天静脉滴入,4周重复1次,共4~6个周期。结果 1、3、5 a生存率单放组分别为58.6%、27.5%、10.3%,综合组分别为75.0%、53.5%、32.1%,综合组高于单放组(P<0.05)。结论高分级脑胶质瘤术后三维适行放疗加同步化疗可提高疗效。
Objective To analyze the effect of three-dimensional adaptive radiotherapy and three-dimensional appropriate radiotherapy plus chemotherapy after high-grade glioma surgery. Methods Fifty-seven patients with high grade gliomas were randomly divided into radiotherapy group (29 cases) and radiotherapy plus chemotherapy group (28 cases). Two groups of patients were started routine three-dimensional adaptive radiotherapy 2 to 4 weeks after surgery, the first day combined with chemotherapy, the program for the teniposide 100 mg, 750 mg of fluorouracil 1 to 5 days intravenously, 4 1 week, a total of 4 to 6 cycles. Results The 1,3,5-year survival rates were 58.6%, 27.5% and 10.3% respectively in the single group and 75.0%, 53.5% and 32.1% respectively in the combined group and those in the combined group (P <0.05). Conclusion High-grade glioma three-dimensional postoperative radiotherapy and concurrent chemotherapy can improve the curative effect.