论文部分内容阅读
目的探讨密钙息合并介入治疗对骨转移癌的临床疗效。方法对４２例骨转移癌患者采用密钙息针剂１００ＩＵ肌注，每日１次，连用７ｄ为１疗程。同时对全组病人采用经皮骨转移病灶供血动脉插管化疗药物灌注，每２０ｄ～３０ｄ介入治疗１次。结果全组４２例共用密钙息１疗程２８例，２疗程８例，３疗程５例，４疗程１例。ＣＲ４例，ＰＲ２８例，止痛有效率为（ＣＲ＋ＰＲ）７６．１％（３２／４２）。治疗前活动能力Ⅰ级＋Ⅱ级为１７例，治疗后为２９例，活动能力有效率为７０．５％（１２／１７）。４２例病人介入治疗前共有骨转移灶总数１６８个，介入治疗共进行１４７例次，每例平均３．５次，治疗后病灶总数减为１４７个，参照实体瘤疗效标准统计ＣＲ６例，ＰＲ１４例，总有效率（ＣＲ＋ＰＲ）为４７．６％（２０／４２）。结论密钙息与骨转移灶供血动脉介入化疗，既能明显缓解骨癌造成的剧痛，同时使转移灶缩小，不失为晚期骨转移癌一种有效治疗手段。
Objective To investigate the clinical effect of dense calcium and interventional therapy on bone metastases. Methods Forty-two cases of bone metastases were treated with intramuscular injection of 100 IU of MCI injection once daily for 7 days. At the same time, the patients in the whole group were perfused with percutaneous bone metastasis lesions and catheterized with chemotherapy drugs, and interventional treatment was performed every 20 days to 30 days. RESULTS: In the whole group of 42 patients, 28 patients shared 28 courses of calcium treatment, 2 courses of treatment, 5 courses of treatment, and 4 courses of treatment. There were 4 cases of CR and 28 cases of PR. The effective rate of analgesia was (CR+PR) 76.1% (32/42). There were 17 patients with grade I+II activity before treatment and 29 patients after treatment. The effective rate of activity was 70.5% (12/17). The total number of bone metastases was 168 before interventional therapy in 42 patients, and 147 interventions were performed in interventional therapy. The average number of cases was 3.5, and the total number of lesions after treatment was reduced to 147. CR6 cases were evaluated according to the standard of curative effect of solid tumors, and 14 cases were PR. The total effective rate (CR+PR) was 47.6% (20/42). Conclusions Interventional chemotherapy for dense calcium and bone metastases, which can not only significantly relieve the pain caused by bone cancer, but also shrink the metastases, is an effective treatment for advanced metastatic bone cancer.