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近年来随着研究的不断深入,越来越多的证据表明小胶质细胞在缺氧缺血环境中参与了神经系统的各种损伤和修复过程,但其具体活化途径和效应发挥机制还有待进一步探究。小胶质细胞所介导的反应与脑缺氧缺血疾病的关系已被肯定,可望通过干预小胶质细胞的免疫炎性反应以减少病理损害,为临床治疗脑缺血性疾病提供新的思路。
In recent years, with the deepening of research, more and more evidences indicate that microglial cells are involved in various injury and repair processes of the nervous system in the hypoxic-ischemic environment, but the specific activation mechanisms and mechanisms of activation are yet to be established Explore further. The relationship between microglial-mediated responses and hypoxic-ischemic brain damage has been affirmed, and it is expected to provide new clinical treatment for ischemic brain diseases by intervening immune-inflammatory responses of microglia to reduce pathological damage Train of thought.