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目的研究幽门螺杆菌（Ｈｐ）的ｉｃｅＡ基因与胃癌、消化性溃疡病的关系。从１２１例患不同胃十二指肠疾病的患者胃活检组织中分离培养Ｈｐ，ＰＣＲ扩增检测Ｈｐ的ｃａｇＡ和ｉｃｅＡ基因。结果胃癌、消化性溃疡及功能性消化不良患者Ｈｐ的ｃａｇＡ基因的阳性率分别为：９１２％、８７１％和８９７％（Ｐ＞０．０５）；而ｉｃｅＡ１基因的阳性率分别为：６８０％、７１０％和６９２％（Ｐ＞０．０５）。结论我们的研究表明Ｈｐ的ｃａｇＡ和ｉｃｅＡ１基因与胃癌及消化性溃疡的发生不相关。
Objective To study the relationship between iceA gene of Helicobacter pylori (Hp) and gastric cancer and peptic ulcer disease. Hp was isolated and cultured from 121 gastric biopsies from patients with different gastroduodenal diseases. The cagA and iceA genes of Hp were detected by PCR. Results The positive rates of cagA gene in gastric cancer, peptic ulcer and functional dyspepsia were 912%, 871% and 897%, respectively (P> 0.05). The positive rate of iceA1 gene Respectively, 68 0%, 71 0% and 69 2% (P> 0.05). Conclusions Our study shows that the cagA and iceA1 genes of Hp are not associated with the development of gastric cancer and peptic ulcer.