论文部分内容阅读
泛素蛋白酶体系统(ubiquitin proteasome system,UPS),是哺乳动物细胞内主要的蛋白质调控系统,可高效并高度选择性地进行细胞内蛋白质的降解,参与和调控多种细胞生物学过程,如细胞周期、基因转录、抗原提呈、细胞分化和凋亡等,对维持细胞的正常生理功能具有重要意义[1]。目前发现的许多遗传性和获得性疾病(如肿瘤、囊性纤维化)的发生都与该系统功能失调有关。同时,随着一些与
Ubiquitin proteasome system (UPS), a major protein regulatory system in mammalian cells, can efficiently and highly selectively degrade intracellular proteins and participate in and regulate a variety of cell biology processes such as cell Cycle, gene transcription, antigen presentation, cell differentiation and apoptosis, etc., to maintain the normal physiological function of cells is of great significance [1]. Many of the current hereditary and acquired diseases (such as cancer and cystic fibrosis) are associated with dysfunction of the system. At the same time, with some and