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目的 研究钠尿肽对胃动力的调节作用。方法 本实验用四道生理记录仪利用传统的全细胞模式的膜片钳技术记录了离体豚鼠胃窦环行肌自发性收缩活动 ,并且观察了CNP对其自发性收缩活动的影响。结果 实验结果表明 :CNP抑制豚鼠胃窦环行肌自发性收缩活动并具有剂量依赖关系 ;鸟苷
Objective To study the regulatory effect of natriuretic peptide on gastric motility. Methods In this study, the spontaneous contractile activity of isolated antrum muscles of gastric antrum of guinea pigs was recorded by a traditional four-cell patch-clamp technique using a four-channel physiological recorder and the effect of CNP on spontaneous contractile activity was observed. Results The experimental results showed that CNP inhibited the spontaneous contractile activity of guinea-pig gastric antral muscle in a dose-dependent manner; guanosine