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目的：探讨ＡｐｏＥ在长期有氧运动中影响纤溶激活作用中的有关机制。方法：以ＡｐｏＥ基因敲除（ＡｐｏＥ－／－）鼠为实验组、以相同遗传背景的Ｃ５７ＢＬ／６Ｊ鼠为对照组建立运动模型。结果：１２周游泳后，对照组鼠ＴＧ（０．９６±０．３０ｖｓ０．５４±０．０７０ｍｍｏｌ／Ｌ，Ｐ＜０．０１）和ＰＡＩ（０．９２±０．０７ｖｓ０．８０±０．０９ＡＵ／ｍｌ，Ｐ＜０．０５）降低，ｔＰＡ升高（０．６０±０．１２ｖｓ１．０４±０．２３ＩＵ／ｍｌ，Ｐ＜０．０１）；而ＡｐｏＥ－／－鼠的ＴＧ（１．２８±０．３４ｖｓ１．２９±０．３２ｍｍｏｌ／Ｌ，Ｐ＞０．０５）和ＰＡＩ（０．７４±０．１０ｖｓ０．７９±０．０４ＡＵ／ｍｌ，Ｐ＞０．０５）均没有显著变化，ｔＰＡ（０．７１±０．１５ｖｓ０．９７±０．１７ＩＵ／ｍｌ，Ｐ＜０．０１）升高。结论：长期有氧运动使对照小鼠纤溶激活作用明显改善，其机制与ＴＧ和含ＡｐｏＥ脂蛋白水平降低导致ＬＲＰ清除ｔＰＡ－ＰＡＩ作用加强、ＰＡＩ抑制作用减弱及ｔＰＡ合成水平增加有关。Ａｐ ｏＥ－／－鼠运动后，ＰＡＩ水平稳定而ｔＰＡ活性增加，提示ｔＰＡ合成作用增强。
Objective: To investigate the mechanism of ApoE affecting fibrinolytic activation in long-term aerobic exercise. Methods: ApoE knockout (ApoE - / -) mice were used as experimental group and C57BL / 6J mice of the same genetic background as control group. Results: After 12 weeks’ swimming, TG (0.96 ± 0.30vs0.54 ± 0.070mmol / L, P <0.01) and PAI (0.92 ± 0.07vs0.80 ± 0.09AU / Ml, P <0.05), tPA increased (0.60 ± 0.12 vs 1.04 ± 0.23 IU / ml, P <0.01) ± 0.34vs1.29 ± 0.32mmol / L, P> 0.05) and PAI (0.74 ± 0.10vs0.79 ± 0.04AU / ml, P> 0.05) (0.71 ± 0.15 vs 0.97 ± 0.17 IU / ml, P <0.01). CONCLUSION: Long-term aerobic exercise significantly improves the fibrinolytic activity in control mice. The mechanism is related to the enhancement of LRP clearance of tPA-PAI, the decrease of PAI inhibition and the increase of tPA synthesis induced by the decrease of TG and ApoE lipoprotein levels. After exercise, PAI levels were stable and tPA activity was increased, suggesting an increased tPA synthesis.