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在过去几十年里,人们对共同表达CD4和CD25的调节性T细胞进行了大量研究。Treg的特征性表型在于其能有效地维持外周免疫耐受和改变天然免疫的能力。但是,到目前为止,Treg的作用机制以及它和其他细胞间相互作用以提供免疫调节的机制仍然不清楚。最近的研究表明,HO1有调节免疫反应的作用,并且HO1催化产生的副产物———一氧化碳(CO)也被证实在Treg抑制性作用中有重要功能。现结合这些研究新进展,对Treg的作用机制作一综述,为Treg的未来研究方向提出新的思路。
In the past few decades, a great deal of research has been conducted on regulatory T cells that co-express CD4 and CD25. The characteristic phenotype of Tregs lies in their ability to effectively maintain peripheral immune tolerance and alter innate immunity. However, to date, the mechanism of action of Tregs and the mechanisms by which they interact with other cells to provide immunomodulation remain unclear. Recent studies have shown that HO1 plays a role in the regulation of the immune response and that the byproduct of HO1 catalysis, carbon monoxide (CO), has also been shown to play an important role in Treg inhibitory effects. Now combined with these new advances in the study of the mechanism of action of Treg are reviewed for the future research of Treg put forward new ideas.