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目的以活性炭作为吸附剂,确定阿霉素在血液灌流法治疗肝癌时所用吸附剂的最佳用量,以减少阿霉素的毒副作用。方法采用含阿霉素的血浆灌注于不同组合量的活性炭柱,用柱切换高效液相色谱法测定阿霉素的灌注前后血药浓度。结果A组(150g×1支)、B组(150g×2支)、C组(150g×3支)、D组(150g×4支)及E组(150g×5支)活性炭柱对阿霉素的吸附率分别为20.19%、27.60%、55.98%、56.42%、57.13%,经方差分析有极显著性差异,经两两比较的q检验,C、D及E组间无显著性差异。结论除D组与E组P>0.05外,其它三个低剂量活性炭组中任意两组皆为P<0.01,故150g×3支活性炭柱为活性炭吸附剂的最佳用量,该用量的确定为血液灌流法治疗肝癌提供了理论依据。
Objective To use activated carbon as an adsorbent to determine the optimal dosage of doxorubicin adsorbent used in hemoperfusion treatment of liver cancer to reduce the side effects of doxorubicin. Methods Adriamycin-loaded plasma was used to perfuse different combinations of activated charcoal columns. The plasma concentrations of doxorubicin before and after perfusion were determined by column-switching high performance liquid chromatography. Results The effects of group A (150g × 1), group B (150g × 2), group C (150g × 3), group D (150g × 4) and group E The sorption rates of vitamins were 20.19%, 27.60%, 55.98%, 56.42% and 57.13%, respectively. There was a significant difference by ANOVA. There was no significant difference between groups C, D and E after q test. Conclusion In addition to the P group of Group D and E 0.05, the other three low-dose activated carbon in any two groups were P <0.01, so 150g × 3 activated carbon column activated carbon adsorption of the best dosage, the amount determined as Hemoperfusion treatment of liver cancer provides a theoretical basis.