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作者研究贮藏时间和相对湿度对四种不同商品的氯霉素胶囊剂的崩解作用和体外释药速度的关系。结果表明:在相对湿度49%或66%中贮藏32周,胶囊剂的崩解时间和药物体外溶解速度虽随时间的延长而有所减小,但并不很明显。四种胶囊剂贮藏在相对湿度80%的容器中,分别在胶囊剂制成的当时、贮藏2周、4周后测定未溶解氯霉素的含量并与其溶解试验时(分钟)间作图,得一级溶解速度图式。贮藏4周者几乎都没有药物释放出来,贮藏二周者,其中二种氯霉素胶囊在30分钟内有85%以上溶解,但其余二种则几无溶解,说明不同商品的胶囊剂的溶解性质是不同的。药物释放速度变劣的
The authors investigated the relationship between storage time and relative humidity on the disintegration and release rates of chloramphenicol capsules from four different commercial products. The results showed that the capsule disintegration time and dissolution rate in vitro decreased with the extension of time but were not obvious when stored at 49% or 66% relative humidity for 32 weeks. Four kinds of capsules were stored in a container of relative humidity of 80%, respectively, at the time of the capsule made, stored for 2 weeks, 4 weeks after the determination of undissolved chloramphenicol content and its dissolution test (minutes) mapping A dissolution rate pattern. Almost no drug was released after 4 weeks of storage and stored for two weeks. Two of the two chloramphenicol capsules dissolved more than 85% in 30 minutes, while the other two were almost insoluble, indicating that dissolution of capsules of different commercial products The nature is different. Poor drug release rate