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本文报道实验性低氧性肺动脉高压（猪）模型在低氧前后及低氧静脉注射小剂量尼群地平后，肺循环，体循环动力学，血管紧张素转换酶（ＡＣＥ），血管紧张素Ⅱ（ＡＴⅡ），血浆肾素活性（ＰＲＡ），血栓素Ａ＿２（ＴＸＡ＿２），前列环素（ＰＧＩ＿２）及血中乳酸含量的变化，结果显示：低氧后，肺动脉压及肺血管阻力增高，右心作功指数，ＰＲＡ，ＡＴⅡ，ＴＸＡ＿２升高，ＡＣＥ及ＰＧＩ＿２降低，ＴＸＡ＿２／ＰＧＩ＿２升高，静注尼群地平后，肺动脉压持续显著下降，肺循环动力学指数下降，体循环无显著变化，血中乳酸及ＰＧＩ＿２含量升高。尼群地平可作为降低缺氧性肺动脉高压药物进一步研究。
This study reports the changes of pulmonary circulation, systemic circulation kinetics, angiotensin converting enzyme (ACE), angiotensin Ⅱ (AT Ⅱ) in experimental hypoxic pulmonary hypertension (pig) model before and after hypoxia and low dose intravenous injection of nitrendipine ), Plasma renin activity (PRA), TXA_2, PGI_2 and blood lactic acid. The results showed that after hypoxia, pulmonary arterial pressure and pulmonary vascular resistance increased, Index, PRA, ATⅡ and TXA_2, ACE and PGI_2 decreased, TXA_2 / PGI_2 increased. After intravenous injection of nitrendipine, pulmonary arterial pressure continued to decrease significantly, pulmonary circulation kinetic index decreased, while systemic circulation did not change significantly. Increased content. Nitrendipine can be used as a hypoxic pulmonary hypertension drug further study.