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目的探讨分析雷贝拉唑联合莫沙比利治疗反流性食管炎的临床疗效。方法将124例反流性食管炎患者随机分为观察组和对照组,分别给予雷贝拉唑联合莫沙比利和奥美拉唑联合莫沙比利治疗,比较两组患者治疗前后临床症状评分、临床疗效、胃镜下食管炎愈合情况及不良反应。结果治疗后观察组临床症状评分低于对照组,临床疗效总有效率、胃镜下食管炎愈合总有效率均显著高于对照组,差异均有统计学意义(P<0.05),两组不良反应发生率比较差异未见统计学意义(χ2=0.701,P=0.403)。结论雷贝拉唑联合莫沙比利治疗反流性食管炎可有效其提高临床疗效,加快食管炎愈合,且不良反应发生率低,安全、可靠,值得推广。
Objective To investigate the clinical efficacy of rabeprazole combined with mosapride in the treatment of reflux esophagitis. Methods 124 cases of reflux esophagitis patients were randomly divided into observation group and control group, rabeprazole combined with mosapride and omeprazole combined with mosapride treatment, the two groups were compared before and after treatment of clinical symptoms score Clinical efficacy, endoscopic esophagitis healing and adverse reactions. Results After treatment, the scores of clinical symptoms in the observation group were lower than those in the control group. The total effective rate of clinical curative effect and the total effective rate of endoscopic esophagitis healing were significantly higher than those in the control group (P <0.05). The two groups of adverse reactions The incidence was no significant difference (χ2 = 0.701, P = 0.403). Conclusion Rabeprazole combined with mosapride in the treatment of reflux esophagitis can be effective in improving clinical curative effect, accelerating the healing of esophagitis, and the incidence of adverse reactions is low, safe, reliable and worthy of promotion.