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血清甲胎蛋白(AFP)的升高用于诊断原发性肝癌有较大价值。但近年来发现,AFP 水平亦可在急慢性肝炎和肝硬化患者中增高。作者等对166例经肝活检证实的慢性乙型肝炎患者,包括男152例,女14例、年龄20～65岁。定期作 AFP、乙肝免疫及常规肝功能测定,平均随防3年。166例慢性乙型肝炎患者在随访期间,22例有29次血清 AFP 水平升高,其中17次<100ng/ml,9次为100～400ng/ml,3次>400ng/ml。29次血清 AFP 升高者有25次(86%)的原因为肝炎暂时性加重,其中11次 AFP 值升高伴有 HBeAg从血清中清除和临床病情缓解。通常开始为血清转氨
Elevated serum alpha-fetoprotein (AFP) is of great value in the diagnosis of primary liver cancer. However, it has been found in recent years that AFP level can also be increased in patients with acute and chronic hepatitis and cirrhosis. The author of 166 patients with chronic hepatitis B confirmed by liver biopsy, including 152 males and 14 females, aged 20 to 65 years. Regular AFP, hepatitis B immunity and routine liver function tests, with an average of anti-3 years. Of 166 patients with chronic hepatitis B, 22 had 29 serum AFP levels during follow-up, of which 17 were <100 ng / ml, 9 were 100-400 ng / ml and 3 were> 400 ng / ml. Thirty-five (86%) of the 29 patients with elevated serum AFP were transiently exacerbated by hepatitis, 11 of which were accompanied by an increase in AFP with clearance of HBeAg from the serum and a remission of the clinical condition. Transfer of serum to serum is usually started