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自1918年应用奎尼丁治疗心律失常以来,六十余年中抗心律失常药物的研究有了很大的进展,虽已找到了很多有效的抗心律失常药,但各有利弊。如利多卡因(Ⅰ)的作用时间短暂,口服无效,却是一个安全的静注抢救危急病人的优良药物。乙胺碘呋酮(Amioda-rone)(Ⅱ)原是一个抗心绞痛药,不良反应小,耐受性佳,由于起效慢,不适用于注射抢救,口服用量大(每日400～800毫克),合成方法比较复杂,成本随而较高。
Since the treatment of arrhythmia by quinidine in 1918, the research on antiarrhythmic drugs has made great progress in more than 60 years. Although many effective antiarrhythmic drugs have been found, they have their own pros and cons. For example, lidocaine (Ⅰ) has a short acting time and is ineffective in oral administration, but it is a safe and excellent medication for intravenous rescue of critical patients. Amioda-rone (Ⅱ) was originally an anti-anginal drug with a small adverse reaction and good tolerability. It is not suitable for injection and rescue because of its slow onset of action. Oral administration is large (400 to 800 mg daily ), The synthesis method is more complex, the cost is higher.