论文部分内容阅读
目的探讨代谢综合征(MS)及其各组分和心脑血管疾病(CVD)之间的关系,为相关疾病的预防提供可靠依据。方法将2009年4月至2011年4月在我院住院的148例MS患者,以及2009-2010年在我院居民健康体检中发现的1056例MS患者作为研究对象。将1204例MS患者按疾病诊断分为冠心病组、脑卒中组、冠心病并发脑卒中组和对照组(无冠心病及脑卒中)。所有患者均晨起空腹抽静脉血检测空腹血糖(FPG)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、糖化血红蛋白,计算稳态模型胰岛素抵抗指数(HOMA-IR);测量坐位血压和腰围;应用彩色多普勒超声诊断仪检查患者颈动脉血管内有无斑块形成。结果冠心病组、脑卒中组、冠心病并发脑卒中组患者的腰围、HOMA-IR、TG、TG/HDL-C明显高于对照组,差异均有统计学意义(P<0.05);冠心病组HDL-C水平明显低于对照组,LDL-C/HDL-C明显高于对照组,差异均有统计学意义(P<0.05);4组患者LDL-C水平的差异无统计学意义(P>0.05)。冠心病组、脑卒中组和冠心病并发脑卒中组患者的高血压、高血糖、颈动脉粥样硬化检出率均明显高于对照组,差异均有统计学意义(P<0.01)。结论控制肥胖的发生和发展是预防MS的重要措施,是早期预防和控制高血压、高血脂、高血糖等慢性疾病的重要措施。
Objective To explore the relationship between metabolic syndrome (MS) and its components and cardiovascular and cerebrovascular diseases (CVD), and to provide a reliable basis for the prevention of related diseases. Methods A total of 148 MS patients hospitalized in our hospital from April 2009 to April 2011 and 1056 MS patients found in the physical examination of residents in our hospital from 2009 to 2010 were studied. According to the disease diagnosis, 1204 MS patients were divided into coronary heart disease group, stroke group, coronary heart disease group and control group (no coronary heart disease and stroke). Fasting blood glucose (FPG), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting insulin (FINS) , HbA1c, HOMA-IR were calculated. Blood pressure and waist circumference were measured. Color Doppler sonography was used to detect plaque formation in carotid arteries of patients. Results The waist circumference, HOMA-IR, TG, TG / HDL-C in CHD group, stroke group and CHD group were significantly higher than those in control group (P <0.05) The level of HDL-C in HDL-C group was significantly lower than that in control group, and the LDL-C / HDL-C level was significantly higher than that in control group (P <0.05). There was no significant difference in LDL- P> 0.05). The detection rates of hypertension, hyperglycemia and carotid atherosclerosis in CHD group, stroke group and CHD group were significantly higher than those in control group (P <0.01). Conclusion Controlling the occurrence and development of obesity is an important measure to prevent MS. It is an important measure to prevent and control chronic diseases such as hypertension, hyperlipidemia and hyperglycemia in the early stage.