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目的 :观察呼吸功能减退患者使用芬太尼后 ,在支气管镜检查 (FOB)中心率 (HR)、血压和血氧饱和度(SpO2 )的变化。方法 :A组 35例为呼吸功能显著减退患者 ,B组 (2 8例 )为对照组 ,两组插镜前以芬太尼 2μg/kg静脉注射 ,于用药前、插镜前、操作中和镜检结束记录收缩压 (SP)、舒张压 (DP)、平均动态压 (MAP)、HR和SpO2 。结果 :与基础值相比 ,镜检中两组HR均有增快 (P <0 .0 1或 0 .0 5 ) ,但SP ,DP ,MAP无显著变化 (P >0 .0 5 ) ,两组镜检中HR ,SP ,DP ,MAP亦无显著性差异 ,A组SpO2 的基础值低于B组 ,表明A组镜检前有低氧血症。镜检中A组SpO2 下降 (P >0 .0 1) ,与基础肺功能显著减损有关。结论 :在支气管镜检查中呼吸功能减退患者使用芬太尼 (2 μg/kg)是安全、有效的 ,能够起到较好的镇静效果和保持血压的稳定。
PURPOSE: To observe the changes of heart rate (HR), blood pressure and oxygen saturation (SpO2) during bronchoscopy (FOB) after using fentanyl in patients with hypothyroidism. Methods: A group of 35 patients with significant decline in respiratory function, B group (28 cases) as the control group, before the two groups were injected fentanyl 2μg / kg intravenously before medication, Systolic pressure (SP), diastolic pressure (DP), mean dynamic pressure (MAP), HR and SpO2 were recorded at the end of the microscopic examination. RESULTS: Compared with the baseline values, both groups of HR increased significantly (P <0.01 or 0.05), but no significant changes in SP, DP and MAP (P> 0.05) There was no significant difference in HR, SP, DP and MAP between the two groups. The basal value of SpO2 in group A was lower than that in group B, indicating hypoxaemia in group A before microscopy. SpO2 in group A was lower than that in group A (P> 0.05), which was related to the significant impairment of basic lung function. CONCLUSIONS: Fentanyl (2 μg / kg) is safe and effective in bronchoscopy for patients with hypothyroidism and is associated with better sedation and blood pressure stability.